Liverpool face Spurs in the game of the weekend, a day after title rivals Manchester City travel to struggling Fulham.
Liverpool snatched three points with a wild 1-0 victory over relegation-threatened Nottingham Forest.
'We knew it was going to be hard to play against them, but I give all the praise to the lads for the hard work.'
Arsenal's Jack Wilshere and Kieran Gibbs are doubtful for the Champions League Group F trip to last season's runners-up Borussia Dortmund with coach Arsene Wenger eager to make amends for last month's loss to the Germans.
Arsenal coach Arsene Wenger will be without right back Mathieu Debuchy for a "longer period" of time and is struggling with defensive options for their Champions League group opener against Dortmund.
Liverpool suffered a shock 2-1 loss to Championship side Wolverhampton Wanderers in the FA Cup fourth round on Saturday, handing manager Juergen Klopp a third home defeat in a row.
It promises to be a tense and thrilling finale to the season but Liverpool, who have frittered away a seven-point lead, will need to regain their momentum quickly if they are to push for their first league title since 1990.
Liverpool ran riot to reach the League Cup semi-finals with a 6-1 thrashing of Southampton on Wednesday in which Divock Origi grabbed a hat-trick and Daniel Sturridge scored twice as the Juergen Klopp juggernaut rolled on.
The reigning champions have won 53 and drawn 11 of those 64 games, scoring 169 goals and conceding 42 for a total of 170 points.
If anyone was still wondering why Liverpool spurned Barcelona's bids for Brazilian playmaker Philippe Coutinho, his part in Saturday's 3-2 win over Leicester City provided the answer.
The league has ruled out a 'pause' to the season to allow clubs to recover their squads, although the surging Omicron variant has put paid to half of the weekend's fixtures including Manchester United's home game with Brighton & Hove Albion.
Loris Karius told fans he was 'infinitely sorry' for his two catastrophic errors in the side's 3-1 defeat to Real Madrid in the Champions League final and said he had struggled to sleep after Saturday's game.
IMAGES from the UEFA Champions League matches played on Wednesday.
News of all that's transpired on and off the football field
Following are facts and figures after Manchester City clinched the Premier League title
Vinicius Junior's second half tap-in steered Real Madrid to a 1-0 victory over Liverpool in the Champions League final on Saturday.
The 32-year-old, who joined Barcelona in 2014, said before the second leg at Anfield that he only had fond memories of his time in England.
Arsenal's Premier League title charge gathered momentum as they moved two points clear at the top with a scrappy 1-0 victory over Newcastle United on Saturday as Leicester City's push faltered with a goalless home draw against Bournemouth.
The loss was the joint-heaviest defeat by a side already crowned Premier League champions. Arsenal were beaten 4-0 at Liverpool in 1997-98 in the game after they clinched the title.
Nuggets of news coming from the English Premier League
Liverpool fielded a starting lineup consisting mainly of reserves and youth team players with an average age of 19.4, a club record.
Whatever happens, there will be no shortage of drama between now and May 12.
Premier League clubs West Bromwich Albion and Watford were knocked out in the League Cup second round by lower-league opponents on Tuesday as a strong Liverpool side crushed championship Burton Albion 5-0.
Arsenal missed the chance to heighten the congestion at the top of the Premier League and suffered fresh injury blows when a frustrating 1-1 draw at Norwich City failed to take them alongside leaders Manchester City and Leicester City on Sunday.
Liverpool manager Juergen Klopp acknowledged that they would have to defend better in the visit to Stamford Bridge to stop Eden Hazard reprising the sort of solo brilliance that propelled Chelsea to victory at Anfield on Wednesday.
Following is a match by match look at the English Premier League's weekend fixtures
Champions Leicester City will begin their Premier League title defence with a trip to newly promoted Hull City on August 13, according to the 2016-17 fixtures released on Wednesday.
Roma didn't expect that Salah and Liverpool would stand between them and a place in the Champions League final.
Chelsea's 0-0 home draw with second-placed United ensured Thomas Tuchel is still undefeated in nine games since replacing Frank Lampard, but it meant they failed to dislodge fourth-placed West Ham United who became Manchester City's 20th successive victims in all competitions on Saturday.
'He has real technical quality and crucially, pace. But we can't be overly concerned with one player though because they have match winners all over the pitch. We need to nullify them on Wednesday.'
Salah's strikes brought him to a remarkable 43 goals in all competitions this season, keeping him at the front of the list of top scorers in Europe
Vibrant Chelsea made it a torrid few days for Liverpool as goals by Willian and Ross Barkley sealed a 2-0 victory to send them through to the FA Cup quarter-finals on Tuesday. Liverpool's 44-match unbeaten streak in the Premier League ended in stunning fashion with a 3-0 defeat at Watford on Saturday and they were rocked again at Stamford Bridge.
Tottenham manager Mauricio Pochettino is readying his squad for a final tilt at the Premier League title, aware that he can ask his players to remain focused on one game at a time when a bulk of them return from the international break.
Leipzig will likely need to find an alternate venue or shift the two-leg tie around and first play in England.
Manchester United produced an utterly unexpected 2-1 victory over old rivals Liverpool in the Premier League at Old Trafford on Monday to turn fan protests against the club's owners into a rare night of celebration.
This was not quite Liverpool back to their best but it was an important statement of intent for Klopp's side that they will not be giving up their title without a fight.
Liverpool continued their relentless march to a first English title in 30 years, easing to a 2-0 victory at West Ham United on Wednesday to move 19 points clear at the Premier League summit. Mohamed Salah fired them ahead from the penalty spot in the first half and Alex Oxlade-Chamberlain doubled their advantage early in the second to wrap up a remarkable 23rd win from 24 games this season and stretch their unbeaten league run to 40.
In other ties, Serie A champions Juventus face Europa League winners Atletico Madrid and Barcelona take on Olympique Lyonnais.
Liverpool charge towards English Premier League title with win at Wolves. Here are images from the match played on Thursday.
Liverpool were on the end of the biggest sensation of the English Premier League season when bottom club Swansea City repelled a dramatic comeback from Juergen Klopp's title chasers to earn their first-ever league win at Anfield.
